Here's his current anti-aging regimen as outlined by Dr Hall: He makes no recommendations for others except "Eat fewer calories", "Don't sweat the small stuff", and "Exercise". For example you can have some whole milk, full fat yogurt, or some nuts. Dr. Sinclair takes 1 gram of resveratrol in the morning mixed in yogurt. There has been some discussion and concern that by increasing the amount of methylation the body needs to do (through supplementation of NR/NMN), we might deplete the body of methyl groups needed to carry out essential processes. Typically Metformin is taken daily both by diabetics, and by people using it for healthspan extension. David Sinclair is a PhD professor and researcher at Harvard. He holds a PhD from the University of New South Wales (Sydney, Australia) and is a Full Professor at Harvard where is working since 1999. Then similarly a more recent European Food Safety Authority document discusses stability (, Lower blood glucose, triglycerides and fasting insulin in patients with type 2 diabetes, Activate the AMPK pathway which, among other things, increases cellular cleanup (autophagy), David is a longevity researcher who is certainly aging gracefully. (2006)15Sirtuin activators mimic caloric restriction and delay ageing in metazoans Sinclair et al. It is also possible to buy spermidine in a pure form. There has been some concern in the field that consuming NR or NMN could decrease the bodys methyl groups and lead to health problems. Below we'll start by looking in detail on each of the supplements that David Sinclair takes. I recently did an Instagram live with Dr David Sinclair, Harvard Medical Scientist, which was phenomenal and so interesting. Examples of wheat germ derived spermidine brands: Examples of spermidine trihydrochloride brands: With resveratrol and NMN, for example, the only way to consume them in large quantities, is via supplementation. However, there isnt yet research on optimal dosage for someone with already healthy blood glucose levels. 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