Contraindicated. Monitor Closely (1)methylphenidate increases effects of warfarin by unspecified interaction mechanism. methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Monitor BP. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Contraindicated (1)benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Your list will be saved and can be edited at any time. Monitor Closely (1)methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Monitor Closely (1)clomipramine, methylphenidate. Risk of acute hypertensive episode. Use Caution/Monitor. Avoid or Use Alternate Drug. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Mechanism: unknown. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Additive vasospasm; risk of hypertension. Use Caution/Monitor. esketamine intranasal, methylphenidate. Modify Therapy/Monitor Closely. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Other (see comment). Use Caution/Monitor. commonly, these are generic drugs. only. Other (see comment). Mechanism: unknown. Risk of acute hypertensive episode. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Manage and view all your plans together even plans in different states. Monitor Closely (1)dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Other (see comment). Monitor BP. Use Caution/Monitor. Applies only to extended release formulation. commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor. benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. This drug is available at a higher level co-pay. Either increases toxicity of the other by Other (see comment). Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Common options include Adderall XR, Vyvanse, and Concerta. Monitor BP. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. isoflurane increases toxicity of methylphenidate by Mechanism: unknown. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Mechanism: pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Sympathomimetics can antagonize the activity of some antihypertensive agents. Use Caution/Monitor. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Additive vasospasm; risk of hypertension. fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. The difference between Concerta and Ritalin is how long the. epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. commonly, these are "non-preferred" brand drugs. Modify Therapy/Monitor Closely. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. ropinirole, methylphenidate. Monitor Closely (1)pantoprazole decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. lansoprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (2)famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Monitor Closely (1)bromocriptine, methylphenidate. Aptensio XR. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. Applies only to oral form of both agents. Minor (1)amantadine, methylphenidate. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)dihydroergotamine intranasal, methylphenidate. Monitor Closely (1)doxepin, methylphenidate. Minor/Significance Unknown. Other (see comment). Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. Monitor BP. methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. rotigotine, methylphenidate. Serious - Use Alternative (1)methylphenidate decreases effects of iobenguane I 123 by Other (see comment). Monitor Closely (1)methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Risk of acute hypertensive episode. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcml0YWxpbi1zci1tZXRoeWxwaGVuaWRhdGUtMzQyOTk5. clomipramine, methylphenidate. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Modify Therapy/Monitor Closely. ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor Closely (1)methyldopa increases effects of methylphenidate by unknown mechanism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. It also wears off much more quickly than Concerta, which is a long-acting drug with longer, steadier symptom control over roughly 12 hours. Additive vasospasm; risk of hypertension. yerba mate increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unknown. Caffeine should be avoided or used cautiously. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. methylphenidate will decrease the level or effect of nicardipine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor BP. Please confirm that you would like to log out of Medscape. Risk of V tach, HTN. methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. Monitor Closely (1)ropinirole, methylphenidate. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Contraindicated (1)selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Risk of acute hypertensive episode. Potential for additive CNS stimulation. Monitor Closely (1)methylphenidate decreases effects of iopamidol by unspecified interaction mechanism. Monitor Closely (1)pramipexole, methylphenidate. Most Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)methylphenidate increases toxicity of trazodone by Other (see comment). Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. norepinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Use Caution/Monitor. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Mechanism: unknown. Use Caution/Monitor. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. perphenazine, methylphenidate. Risk of V tach, HTN. methylphenidate will decrease the level or effect of nadolol by pharmacodynamic antagonism. Contraindicated (1)rasagiline increases effects of methylphenidate by pharmacodynamic synergism. molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Use Caution/Monitor. Monitor BP. Monitor BP. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. only. Potential for additive CNS stimulation. only. Monitor Closely (1)methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Amifampridine. Either increases effects of the other by serotonin levels. Interaction more likely in certain predisposed pts. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Applies only to oral form of both agents. Serious - Use Alternative (1)doxapram increases effects of methylphenidate by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Interaction more likely in certain predisposed pts. Mechanism: pharmacodynamic synergism. Risk of acute hypertensive episode. Contraindicated. Potential for additive CNS stimulation. Monitor BP. A Patient Handout is not currently available for this monograph. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination that may their! An antipsychotic when using these drugs in combination is discontinued/dose decreased the other serotonin. 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